QBS 133 Clinical Epidemiology

Evidence-based medicine is the cornerstone of contemporary clinical practice. Clinical epidemiology aims to quantitatively evaluate medical interventions and technology and advance prediction and decision support tools to guide medical practice. The principles, tools and statistical approaches of clinical epidemiology are widely applicable in academic research, healthcare, and industry settings. In this course, students will learn to design and analyze both randomized and observational studies evaluating the efficacy of medical interventions, therapies, devices, screening programs and tests in order to understand therapeutic efficacy, therapeutic safety, and disease prognosis. Additional topics include the construction and validation of clinical risk prediction models (including discrimination, calibration, and reclassification), synthesis of quantitative data for medical decision making (such as meta-analysis), and cost-effectiveness analysis. The course draws on examples from pharmacoepidemiology, pharmacogenomics, real problems faced by medical professionals, and novel examples of clinical research.

Instructor

Dr. Michael Passarelli

Prerequisite

Fundamentals of Epidemiology I (QBS 130) or instructor permission