QBS 132 Molecular Biologic Markers in Human Health Studies

Epidemiologists are moving quickly from a more traditional collection of subjects and observational data towards the incorporation of molecular markers of exposure, disease, and susceptibility. Technologies are rapidly changing, and the incorporation of molecular targets is an added layer of complexity to epidemiology study designs. In this course, students will be exposed to the general framework of what molecular epidemiology encompasses. Each week, the class will examine these challenges and the potential tools to address molecular epidemiology questions. The first half of the course will introduce the students to the historical background, basic definitions and principles in molecular epidemiology designs, use of biomarkers in a study, statistical and bioinformatic challenges in molecular epidemiology, practical aspects such as identifying susceptible populations, exposure assessment and dose-response, molecular classification of phenotypes, evaluating study compliance, monitoring, testing efficacy molecularly, and predicting prognosis. The second part of the class will be dedicated to applications in different fields (e.g., cancer, neurodegenerative diseases, infectious diseases, cardiovascular diseases, etc.). The students will design a short applied project section and briefly present taking turns in each class (e.g., validation of a biomarker, biobanking of human biofluids, or tissue specimens). Students will be encouraged to choose a topic relevant to their research interests. 

Instructor

Lucas Salas

Prerequisite

No prerequisites are needed for this course; however, the students are encouraged to co-enroll in QBS 130.